Protein kinase modulators and methods of use

This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, th...

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Hauptverfasser:	Buhr, Chris A, Baik, Tae-Gon, Ma, Sunghoon, Tesfai, Zerom, Wang, Longcheng, Co, Erick Wang, Epshteyn, Sergey, Kennedy, Abigail R, Chen, Baili, Dubenko, Larisa, Anand, Neel Kumar, Tsang, Tsze H, Nuss, John M, Peto, Csaba J, Rice, Kenneth D, Ibrahim, Mohamed Abdulkader, Schnepp, Kevin Luke, Shi, Xian, Leahy, James William, Chen, Jeff, Dalrymple, Lisa Esther, Forsyth, Timothy Patrick, Huynh, Tai Phat, Mann, Grace, Mann, Larry Wayne, Takeuchi, Craig Stacy, Lamb, Peter, Matthews, David J, Miller, Nicole
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.