Optimal selection of compression entries for compressing program instructions

A method of compressing instructions in a program may include extracting unique bit patterns from the instructions in the program and constructing a linear programming formulation or an integer programming formulation from the unique bit patterns, the instructions, and/or the size of a memory storage. The linear programming formulation or the integer programming formulation may be solved to produce a solution. The method may include compressing at least some of the instructions based on the solution by storing at least some of the unique bit patterns in a memory and placing corresponding indices to the memory in new compressed instructions.