Methods of treatment of autoimmune diseases using humanized immunoglobulin reactive with B7-2

The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders a...

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Bibliographische Detailangaben
Hauptverfasser: Co, Man Sung, Vasquez, Maximiliano, Carreno, Beatriz, Celniker, Abbie Cheryl, Collins, Mary, Goldman, Samuel, Gray, Gary S, Knight, Andrea, O'Hara, Denise, Rup, Bonita, Veldman, Geertruida M
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.