Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors

The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McDevitt, Robert E, Li, Yanfang, Robichaud, Albert J, Heffernan, Gavin D, Coghlan, Richard D, Bernotas, Ronald C
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5-hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.