Devices and processes for distribution of genetic material to mammalian limb

A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from Muscular Dystrophy. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining...

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Bibliographische Detailangaben
Hauptverfasser: Budker, Vladimir G, Wolff, Jon A
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from Muscular Dystrophy. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.