System and method of operating microfabricated ultrasonic transducers for harmonic imaging

A capacitive microfabricated ultrasonic transducer (cMUT) is operated to improve its performance during harmonic imaging in non-linear media, such as in contrast agents or in human tissue. The cMUT is operated by inverting the transmit waveform to adjacently spaced azimuth elements, and combining at least two additional firings without adjacent inversion, for each transmit vector, thereby canceling the second harmonic generation of the cMUT; and thus, the performance of harmonic imaging using the cMUTs can achieve improvement.