Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)

1234 85 586 887 83328 This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R, R, R, and Rare each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; Ris H, alkyl, perfluoroalkyl, aryl option...

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Hauptverfasser: Crandall, David LeRoy, Mayer, Scott Christian, Gundersen, Eric Gould, Elokdah, Hassan Mahmoud
Format: Patent
Sprache:eng
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Zusammenfassung:1234 85 586 887 83328 This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R, R, R, and Rare each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; Ris H, alkyl, perfluoroalkyl, aryl optionally substituted with R, alkanoyl, aroyl optionally substituted with R; Ris H, alkyl, alkylaryl, benzyl optionally substituted with R, alkanoyl, aroyl optionally substituted with R; Ris H, alkyl, alkylaryl, aryl optionally substituted with R; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SOH, POH, tetronic acid, etc.; Ris H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.