Andrographolide and analogues as inhibitors of TNFα and IL-1β expression

Andrographolide and analogues as inhibitors of TNFα and IL-1β expression

1 2 This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein Rand Rare defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.

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Bibliographische Detailangaben
Hauptverfasser: Yan, Xiaoqiang, Wang, Tao, Ma, Zhiming, Pan, Ke, Zhang, Weihan, Hong, Jianrong, Duan, Jeff, Cai, Yu
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:1 2 This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein Rand Rare defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.