I/O protection under over-voltage and back-drive conditions by single well charging

In an I/O driver that includes a cascoded pair of PMOS driver transistors connected to a pair of cascaded NMOS driver transistors and that defines a pad output between the PMOS and NMOS driver transistors, a method of providing the CMOS I/O driver with over-voltage and back-drive protection includes providing circuitry for charging the wells of the PMOS transistors either to VDDIO during normal voltage mode by making use of the power supply, or to a common voltage during over-voltage and back-drive operation using the pad voltage.