Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof

Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof

The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to s...

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Hauptverfasser: Wilks, Andrew Frederick, Burns, Christopher John, Fantino, Emmanuelle, Lucet, Isabelle, Rossjohn, Jamie, Styles, Michelle Leanne
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.