Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase

Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase

The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.

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Bibliographische Detailangaben
Hauptverfasser: Evdokimov, Artem Gennady, Kawamoto, Richard Masaru, Boyer, Angelique Sun, Mekel, Marlene Jan, Pokross, Matthew Eugene, Walter, Jr, Richard Lee
Format: Patent
Sprache:eng
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Zusammenfassung:The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.