Pyrimidine derivatives for treatment of hyperproliferative disorders

Pyrimidine derivatives for treatment of hyperproliferative disorders

22a Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R, G, G′, and G″ represent substituent groups and Rrepresents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and metho...

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Hauptverfasser: Dixon, Julie A, Nagarathnam, Dhanapalan, Zhang, Lei, Wang, Chunguang, Yi, Lin, Chen, Yuanwei, Chen, Jianqing, Bear, Brian R, Brands, Michael, Hillisch, Alexander, Bierer, Donald, Wang, Ming, Fu, Wenlang, Hentemann, Martin F, Bullion, Ann-Marie, Patel, Manoj
Format: Patent
Sprache:eng
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Zusammenfassung:22a Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R, G, G′, and G″ represent substituent groups and Rrepresents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.