Enzymatic activities in chemokine-mediated inflammation

Enzymatic activities in chemokine-mediated inflammation

Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability o...

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Bibliographische Detailangaben
Hauptverfasser: Berahovich, Robert D, Miao, Zhenhua, Premack, Brett, Schall, Thomas J
Format: Patent
Sprache:eng
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Zusammenfassung:Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.