PAI-2 conjugates for the treatment and imaging of cancer

A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ranson, Marie, Allen, Barry John, Bunn, Clive Leighton
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.