Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure

The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brancaccio, Mara, Silengo, Lorenzo, Altruda, Fiorella, Lembo, Giuseppe, Fratta, Luigi, Tarone, Guido
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies are heart failure, and in particular diluted cardiomyopathy.