GSK-3 inhibitors

GSK-3 inhibitors

1 Provided are thiadiazolidine compounds of formula I wherein Ris an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3...

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Bibliographische Detailangaben
Hauptverfasser: Padilla, Miguel Medina, Cascón, Mercedes Alonso, Díaz, Isabel Dorronsoro, Gil, Ana Martínez, del Pliego, Gema Panizo, Huerta, Ana Fuertes, Puerto, María José Pérez
Format: Patent
Sprache:eng
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Zusammenfassung:1 Provided are thiadiazolidine compounds of formula I wherein Ris an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury.