Thiazole compounds and methods of use

Thiazole compounds and methods of use

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and...

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Bibliographische Detailangaben
Hauptverfasser: Zeng, Qingping, Allen, John G, Bourbeau, Matthew P, Dominguez, Celia, Fotsch, Christopher H, Han, Nianhe, Hong, Fang-Tsao, Huang, Xin, Lee, Matthew R, Li, Aiwen, Liu, Qingyian, Rider, James T, Tadesse, Seifu, Tasker, Andrew S, Viswanadhan, Vellarkad N, Wang, Xianghong, Weiler, Kurt E, Wohlhieter, George E, Yao, Guomin, Yuan, Chester Chenguang
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.