Heteroaryl amines as glycogen synthase kinase 3β inhibitors (GSK3 inhibitors)
1 1-61-61-61-61-62 1-102-102-103 1-62-62-61-61-61-61-61-61-61-61-621211-621212121p7p7p21p727217214 2 3 This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered...
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Zusammenfassung: | 1 1-61-61-61-61-62 1-102-102-103 1-62-62-61-61-61-61-61-61-61-61-621211-621212121p7p7p21p727217214 2 3 This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted CalkyloxyCalkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhaloCalkyloxy; polyhaloCalkylthio; R; R-Calkyl; R-O-; R-S-; R-C(═O)-; R-S(═O)-; R-S(═O)-; R-S(═O)-NH-; R-S(═O)-NH-; R-C(═O)-; -NHC(═O)H; -C(═O)NHNH; R-C(═O)-NH-; R-C(═O)-NH-; -C(═NH)R-C(═NH)R; Ris an optionally substituted heterocycle provided that -X-Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation. |
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