Heteroaryl amines as glycogen synthase kinase 3β inhibitors (GSK3 inhibitors)

1 1-61-61-61-61-62 1-102-102-103 1-62-62-61-61-61-61-61-61-61-61-621211-621212121p7p7p21p727217214 2 3 This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered...

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Hauptverfasser: Freyne, Eddy Jean Edgard, Buijnsters, Peter Jacobus Johannes Antonius, Willems, Marc, Embrechts, Werner Constant Johan, Love, Christopher John, Janssen, Paul Adriaan Jan, Lewi, Paulus Joannes, Heeres, Jan, de Jonge, Marc René, Koymans, Lucien Maria Henricus, Vinkers, Hendrik Maarten, Van Aken, Koen Jeanne Alfons, Diels, Gaston Stanislas Marcella
Format: Patent
Sprache:eng
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Zusammenfassung:1 1-61-61-61-61-62 1-102-102-103 1-62-62-61-61-61-61-61-61-61-61-621211-621212121p7p7p21p727217214 2 3 This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted CalkyloxyCalkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhaloCalkyloxy; polyhaloCalkylthio; R; R-Calkyl; R-O-; R-S-; R-C(═O)-; R-S(═O)-; R-S(═O)-; R-S(═O)-NH-; R-S(═O)-NH-; R-C(═O)-; -NHC(═O)H; -C(═O)NHNH; R-C(═O)-NH-; R-C(═O)-NH-; -C(═NH)R-C(═NH)R; Ris an optionally substituted heterocycle provided that -X-Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.