Genetically modified tumor-targeted bacteria with reduced virulence

Salmonella Salmonella Salmonella The present invention is directed to mutant sp. having a genetically modified msbB gene in which the mutant is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant for growth inhibition and/or reduction in volu...

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Bibliographische Detailangaben
Hauptverfasser: Bermudes, David, Low, Kenneth Brooks
Format: Patent
Sprache:eng
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Zusammenfassung:Salmonella Salmonella Salmonella The present invention is directed to mutant sp. having a genetically modified msbB gene in which the mutant is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant for growth inhibition and/or reduction in volume of solid tumors.