Methods of structured placement of a circuit design

A method of creating relatively placed macros (RPMS) for a circuit design for a target device can include determining N best configurations for each of a plurality of connections of the circuit design, wherein each configuration specifies relative positioning of a source and a load of a connection and an estimated delay for the connection. The method can include calculating a maximum allowable delay for each of the plurality of connections of the circuit design and determining that a connection selected from the plurality of connections is critical according to the N best configurations associated with the critical connection and the maximum delay of the critical connection. A configuration from the N best configurations associated with the critical connection can be selected. An RPM for the critical connection can be generated using the selected configuration.