Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone

Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone

4-Trifluoromethyl-2(1H)-pyridinone is prepared by reaction of 4-alkoxy-1,1,1-trifluorobut-3-en-2-one or 4,4-dialkoxy-1,1,1-trifluorobutan-2-one with a trialkyl phosphonoacetate followed by cyclization.

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Bibliographische Detailangaben
Hauptverfasser: Hamilton, Christopher Thomas, Gullo, Michael Frederick, Gonzalez, Michael Allen, Roth, Gary Alan, Gorman, David Bruce, Gebhardt, Joachim, Götz, Norbert, Jaedicke, Hagen, Mayer, Guido, Rack, Michael
Format: Patent
Sprache:eng
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Zusammenfassung:4-Trifluoromethyl-2(1H)-pyridinone is prepared by reaction of 4-alkoxy-1,1,1-trifluorobut-3-en-2-one or 4,4-dialkoxy-1,1,1-trifluorobutan-2-one with a trialkyl phosphonoacetate followed by cyclization.