Antidiabetic bicyclic compounds

Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particula...

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Bibliographische Detailangaben
Hauptverfasser: Ge, Min, He, Jiafang, Lau, Fiona Wai Yu, Liang, Gui-Bai, Lin, Songnian, Liu, Weiguo, Walsh, Shawn P, Yang, Lihu
Format: Patent
Sprache:eng
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Zusammenfassung:Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.