Amlodipine gentisate and a method of its preparation

The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Jae-Sun, Choi, Jin Young, Ryu, Je Ho, Lee, Nam Kyu, Jang, Jeong-soo, Jang, Woo Jae, Um, Key An, Kum, Do Seung
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.