Small molecule entry inhibitors

The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	De Bethune, Marie-Pierre T. M. M. G, De Meyer, Sandra, Hertogs, Kurt, Lu, Rong Jian, Michiels, Lieve Emma Jan, Tahri, Abdellah, Xie, Dong, Eissenstat, Michael
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.