Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient

Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient

Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising 'GMV' (giant multivesicular) liposomes and methods for their...

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Bibliographische Detailangaben
Hauptverfasser: Bolotin, Elijah M, Grant, Gilbert J, Barenholz, Yechezkel, Turndorf, Herman, Piskoun, Boris
Format: Patent
Sprache:eng
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Zusammenfassung:Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising 'GMV' (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.