Prodrugs of thrombin inhibitors

Prodrugs of thrombin inhibitors

1221 2 There is provided compounds of formula I, RO(O)C-CH-(R)Cgl-Aze-Pab-RI wherein Rand Rhave meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is...

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Bibliographische Detailangaben
Hauptverfasser: Antonsson, Thomas, Gustafsson, David, Hoffmann, Kurt-Jürgen, Nyström, Jan-Erik, Sörensen, Henrik, Sellén, Mikael
Format: Patent
Sprache:eng
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Zusammenfassung:1221 2 There is provided compounds of formula I, RO(O)C-CH-(R)Cgl-Aze-Pab-RI wherein Rand Rhave meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.