Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates

Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates

1 1-6 A process is provided for the preparation of branched-chain ribonucleosides of formula (I): from the 1,2-anhydroderivatives of formula (II). wherein PG is a hydroxyl protecting group, B is a purine or pyrimidine nucleobase, and Ris Calkyl. The compounds of formula (I) are inhibitors of HCV pol...

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Hauptverfasser: Xu, Feng, Bio, Matthew M, Cowden, Cameron, Petrillo, Kimberly A, Williams, J. Michael, Yang, Chunhua, Waters, Marjorie See
Format: Patent
Sprache:eng
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Zusammenfassung:1 1-6 A process is provided for the preparation of branched-chain ribonucleosides of formula (I): from the 1,2-anhydroderivatives of formula (II). wherein PG is a hydroxyl protecting group, B is a purine or pyrimidine nucleobase, and Ris Calkyl. The compounds of formula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.