Cathepsin S inhibitors

This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates t...

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Bibliographische Detailangaben
Hauptverfasser: Hickey, Eugene R, Liu, Weimin, Sun, Sanxing, Ward, Yancey David, Young, Erick Richard Roush
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such compounds and pharmaceutical compositions comprising them