Compositions and methods for elimination of unwanted cells

Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a host cell containing the recombinant vector and expressing the syncytium inducing polypeptide on its cell...

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Bibliographische Detailangaben
Hauptverfasser: Russell, Stephen James, Morling, Frances Joanne, Fielding, Adele Kay, Cosset, Francois-Loic, Cattaneo, Roberto
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a host cell containing the recombinant vector and expressing the syncytium inducing polypeptide on its cell surface, the vectors and resultant host cells expressing the syncytium inducing polypeptide being useful for selective elimination of unwanted cells.