3-phenylpropionic acid derivatives

1411011011021102216 The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or -COO-C-C-alkyl group; Y represents NH, N-C-C-alkyl, O, or S; Z represents NH, N-C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C-C-alkyl, N-aryl, NSO-C-C-alkyl, N-SO-aryl, or N-SO-heteroaryl; R, to Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.