Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives

1 1-61-61-61-6113-62 1-61-61-61-61-634 5 1-61-61-61-61-61-61 22221 2 1 2 This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; Ris hydrogen, Calkyl, Calkyloxy, Calkylthio, amino, mono- or di(Calkyl)amino, Ar, ArNH-, Ccycloalkyl, hydroxymethyl or benzoyloxymethyl; Ris hydrogen, Calkyl, amino, aminocarbonyl, mono- or di(Calkyl)amino, Calkyloxycarbonyl, Calkylcarbonylamino, hydroxy or Calkyloxy; R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, trifluoromethyl, nitro, amino, cyano, azido, CalkyloxyCalkyl, Calkylthio, Calkyloxycarbonyl or Het; is Ar, ArCH- or Het; Arand Aroptionally substituted phenyl; Hetand Hetare optionally substituted monocyclic heterocycles; having angiogenesis inhibiting activity; their preparation, compositions containing them and their use as a medicine.