Asymmetric reduction of 1,1,1-trifluoroacetone

The invention relates to a scalable biocatalytic process for the preparation of S-1,1,1-trifluoro-2-propanol with a enantiomeric excess of >99% by asymmetric microbial reduction of 1,1,1-trifluoroacetone with Baker's yeast.

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Bibliographische Detailangaben
Hauptverfasser: Doswald, Stephan, Hanlon, Steven Paul, Kupfer, Ernst
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a scalable biocatalytic process for the preparation of S-1,1,1-trifluoro-2-propanol with a enantiomeric excess of >99% by asymmetric microbial reduction of 1,1,1-trifluoroacetone with Baker's yeast.