N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives

N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives

NC12523 Disclosed are compounds of the formula wherein the variables R, R, R, R, R, and Rare as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

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Bibliographische Detailangaben
Hauptverfasser: John, Varghese, Maillard, Michel, Jagodzinska, Barbara, Beck, James, Gailunas, Andrea, Freskos, John, Mickelson, John, Samala, Lakshman, Sealy, Jennifer, TenBrink, Ruth, Fang, Lawrence, Hom, Roy
Format: Patent
Sprache:eng
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Zusammenfassung:NC12523 Disclosed are compounds of the formula wherein the variables R, R, R, R, R, and Rare as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.