Manufacture and purification of cyclosporin A

Manufacture and purification of cyclosporin A

Fusarium solani The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and...

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Bibliographische Detailangaben
Hauptverfasser: Khedkar, Anand Prakash, Subramaniyam, Pampapathy, Anand, Konayakanahalli Nanjunda Swamy, Ramkrishna, Melarkode, Tambe, Shreehas Pradeep, Ganesh, Sambasivam, Sircar, Anindya, Suryanarayan, Shrikumar
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Fusarium solani The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.