N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

1 2 10nm103 16165 6 Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(═O) or formula C(═O)NH(OH); Rrepresents hydrogen, methyl or trifluromethyl, or except when Z is a ra...

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Hauptverfasser: Beckett, Paul Raymond, Launchbury, Steven, Pain, Gilles, Pratt, Lisa Marie
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creator Beckett, Paul Raymond
Launchbury, Steven
Pain, Gilles
Pratt, Lisa Marie
description 1 2 10nm103 16165 6 Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(═O) or formula C(═O)NH(OH); Rrepresents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -N(OH)(═O), a hydroxy, halo or amino group; Rrepresents a group R-(X)-(ALK)- wherein R, ALK, X, m and n are as defined in the specification; Rrepresents hydrogen, (C-C) alkyl or phenyl(C-C)alkyl-; and Rand Rare as defined in the specification.
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title N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
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