N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

1 2 10nm103 16165 6 Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(═O) or formula C(═O)NH(OH); Rrepresents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -N(OH)(═O), a hydroxy, halo or amino group; Rrepresents a group R-(X)-(ALK)- wherein R, ALK, X, m and n are as defined in the specification; Rrepresents hydrogen, (C-C) alkyl or phenyl(C-C)alkyl-; and Rand Rare as defined in the specification.