Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B

Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B

The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.

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Bibliographische Detailangaben
Hauptverfasser: Benigni, Daniel, Stankavage, Robert, Chiang, Shu-Jen, Hou, Hsing, Eagan, Bruce, Gu, Dennis, Hou, David, Mintzmyer, Les, Tully, Thomas P, Davis, Brian L, Hargro, Ivan, Mascari, Mark, Galvin, Gabriel, Stein, Gregory, McConlogue, Cary W, Comezoglu, Fahri T
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.