4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors

4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors

123456 7 Phenylamino benzhydroxamic acid derivatives of the formula where R, R, R, R, R, and Rare hydrogen or substituent groups such as alkyl, and where Ris hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases s...

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Hauptverfasser: Barrett, Stephen Douglas, Bridges, Alexander James, Doherty, Annette Marian, Dudley, David Thomas, Saltiel, Alan Robert, Tecle, Haile
Format: Patent
Sprache:eng
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Zusammenfassung:123456 7 Phenylamino benzhydroxamic acid derivatives of the formula where R, R, R, R, R, and Rare hydrogen or substituent groups such as alkyl, and where Ris hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.