Azole compound and medicinal use thereof

7117 7 123 4 2m891085 6 s12st13141422142 The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is -COOR, -X-A-COOR(Ris H, alkyl) or tetrazolyl; R, R, Rand Rare H and the like; A is -(CH)-X- (X is -N(R)-, -C(R)(R)-, -CO- or -CO-N(R)-); B is aryl or aromatic heterocyclic group; Ris H and the like; Ris -(Y)-(A)-Z (Y is -O-, -S(O)-, -N(R)-, -N(R)-CO-, -N(R)-SO-, -SO-N(R)- and the like, Ais alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.