Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors

A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine...

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Bibliographische Detailangaben
Hauptverfasser: Cann, Reginald O, Delaney, Edward J, Fan, Junying, Parlanti, Luca
Format: Patent
Sprache:eng
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Zusammenfassung:A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine to form the amide II.