Crystals of an acyl carrier protein synthase/acyl carrier protein complex

Crystals of an acyl carrier protein synthase/acyl carrier protein complex

B. subtilis This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites...

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Bibliographische Detailangaben
Hauptverfasser: Parris, Kevin Delos, Somers, William Stuart, Tam, Amy Szepui, Lin, Laura Long, Stahl, Mark Lloyd
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:B. subtilis This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.