HIV inhibiting pyrimidines derivatives
123412341 1-61-61-61-61-62 1-63-72-62-61-61-61-6p6p6666 1 51-4p21-41-423 13131413131415161-61-61-62-62-62-61-681-47374 1-63-71-61-61-61-61-61-4 This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and th...
Gespeichert in:
Hauptverfasser: | , , , , , , , , |
---|---|
Format: | Patent |
Sprache: | eng |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | 123412341 1-61-61-61-61-62 1-63-72-62-61-61-61-6p6p6666 1 51-4p21-41-423 13131413131415161-61-61-62-62-62-61-681-47374 1-63-71-61-61-61-61-61-4 This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing −a=a−a=a-and −b=b−b=brepresents pheynl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; Ris hydrogen; aryl; formyl; Calkylcarbonyl; Calkyl; Calkyloxycarbonyl, substituted Calkyl, Calkylcarbonyl; Ris hydroxy, halo, optionally substituted Calkyl, Ccycloalkyl, optionally substituted Calkenyl, optionally substituted Calkynyl, Calkyloxy, Calkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(Calkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(═O)R, -NH-S(═O)R, -C(═O)R, -NHC(═O)H, -C(═O)NHNH?2?, -NHC(═O)R, -C(═NH)Ror a 5-membered hetrocycl; Xis -NR-, -NH-NH-, -N═N-, -O-, -C(═O)-, Calkanediyl, -CHOH-, -S-, -S(═O)-, -X-Calkanediyl- or -Calkanediyl-X-; Ris NHR, NRR; -C(═O)-NHR; -C(═O)-NRR; -C(═O)-R; -CH═N-NH-C(═O)-R; substituted Calkyl; optionally substituted CalkyloxyCalkyl; substituted Calkenyl; substituted Calkynyl; substituted Calkylenyl; Calkyl substituted with hydroxy and a second substituent; -C(═N-O-R)-Calkyl; R; or -X-R; Ris halo, hydroxy, Calkyl, Ccycloalkyl, Calkyloxy, cyano, nitro, polyhaloCalkyl, polyhaloCalkyloxy, aminocarbonyl, Calkyloxycarbonyl, Calkylcarbonyl, formyl, amino, mono- or di(Calkyl) amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them |
---|