HIV inhibiting pyrimidines derivatives

123412341 1-61-61-61-61-62 1-63-72-62-61-61-61-6p6p6666 1 51-4p21-41-423 13131413131415161-61-61-62-62-62-61-681-47374 1-63-71-61-61-61-61-61-4 This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and th...

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Hauptverfasser: Guillemont, Jérôme Emile Georges, Palandjian, Patrice, de Jonge, Marc René, Koymans, Lucien Maria Henricus, Vinkers, Hendrik Maarten, Daeyaert, Frederik Frans Desiré, Heeres, Jan, Van Aken, Koen Jeanne Alfons, Lewi, Paulus Joannes
Format: Patent
Sprache:eng
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Zusammenfassung:123412341 1-61-61-61-61-62 1-63-72-62-61-61-61-6p6p6666 1 51-4p21-41-423 13131413131415161-61-61-62-62-62-61-681-47374 1-63-71-61-61-61-61-61-4 This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing −a=a−a=a-and −b=b−b=brepresents pheynl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; Ris hydrogen; aryl; formyl; Calkylcarbonyl; Calkyl; Calkyloxycarbonyl, substituted Calkyl, Calkylcarbonyl; Ris hydroxy, halo, optionally substituted Calkyl, Ccycloalkyl, optionally substituted Calkenyl, optionally substituted Calkynyl, Calkyloxy, Calkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(Calkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(═O)R, -NH-S(═O)R, -C(═O)R, -NHC(═O)H, -C(═O)NHNH?2?, -NHC(═O)R, -C(═NH)Ror a 5-membered hetrocycl; Xis -NR-, -NH-NH-, -N═N-, -O-, -C(═O)-, Calkanediyl, -CHOH-, -S-, -S(═O)-, -X-Calkanediyl- or -Calkanediyl-X-; Ris NHR, NRR; -C(═O)-NHR; -C(═O)-NRR; -C(═O)-R; -CH═N-NH-C(═O)-R; substituted Calkyl; optionally substituted CalkyloxyCalkyl; substituted Calkenyl; substituted Calkynyl; substituted Calkylenyl; Calkyl substituted with hydroxy and a second substituent; -C(═N-O-R)-Calkyl; R; or -X-R; Ris halo, hydroxy, Calkyl, Ccycloalkyl, Calkyloxy, cyano, nitro, polyhaloCalkyl, polyhaloCalkyloxy, aminocarbonyl, Calkyloxycarbonyl, Calkylcarbonyl, formyl, amino, mono- or di(Calkyl) amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them