System and method for dynamically configuring an information handling system

A system and method for dynamically configuring an information handling system includes a configurable backplane having one or more connectors, at least one switch, one or more terminations, and at least one sense engine. The switch includes an open state and a closed state while the terminations include an active state and an inactive state. The sense engine interfaces with the connectors, the switch, and the terminations and detects peripheral attachments to the connectors. Based on the detection information, the sense engine determines if the switch should be in the open or closed state and determines whether each termination should be in the active or inactive state. The sense engine alters the switch setting and the termination states.