Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade

Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade

The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

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Bibliographische Detailangaben
Hauptverfasser: South, Michael S, Webber, Ronald K, Huang, Horng-Chih, Toth, Mihaly V, Moormann, Alan E, Snyder, Jeffery S, Scholten, Jeffrey A, Garland, Danny J, Rueppel, Melvin L, Neumann, William L, Long, Scott, Huang, Wei, Trujillo, John, Parlow, John J, Jones, Darin E, Case, Brenda, Hayes, Michael J
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.