Agent for preventing/ameliorating obesity comprising methylidene hydrizide compound as active ingredient

1 2 3 2 3 4 4 78910 211 378 9 10 1 The present invention provides a low-molecular inhibitor of GIP functions and, further, an agent for preventing/ameliorating obesity based on inhibition of GIP functions, which comprises, as an active ingredient, a compound represented by the following general formula (I): (wherein Rrepresents hydrogen, halogen, a nitro group or a cyano group, Rand Reach represent hydrogen or halogen, hydrogen or a methoxy group, or both Rand Rmay form an optionally substituted benzene or pyrrole ring, and A represents nitrogen or C-Rwhereupon Rrepresents hydrogen, an optionally substituted C1 to C6 alkyl group, -OR, -NRR, -NHCO-Ror -SO-Ror may, together with R, form an optionally substituted benzene or pyrrole ring, R, Rand Reach represent hydrogen or an optionally substituted C1 to C6 alkyl group, Rrepresents a C1 to C6 alkyl group or the like, and Rrepresents an optionally substituted morpholyl group or the like) or a pharmaceutically acceptable salt thereof.