37-kDa surface adhesin a protein

Streptococcus pneumoniaeStreptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae The invention provides a nucleic acid encoding the 37-kDa protein from . Also provided are isolated nucleic acids comprising a unique fragment of at le...

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Bibliographische Detailangaben
Hauptverfasser: Sampson, Jacquelyn, Russell, Harold, Tharpe, Jean A, Ades, Edwin W, Carlone, George M
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Streptococcus pneumoniaeStreptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae The invention provides a nucleic acid encoding the 37-kDa protein from . Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are antibodies which selectively binds the polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are vaccines comprising immunogenic polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Further provided is a method of detecting the presence of in a sample comprising the steps of contacting a sample suspected of containing with nucleic acid primers capable of hybridizing to a nucleic acid comprising a portion of the nucleic acid encoding the 37-kDa protein, amplifying the nucleic acid and detecting the presence of an amplification product, the presence of the amplification product indicating the presence of in the sample. Further provided are methods of detecting the presence of in a sample using antibodies or antigens, methods of preventing and treating infection in a subject.