Pyrimidine derivatives as IL-8 receptor antagonists

Pyrimidine derivatives as IL-8 receptor antagonists

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen...

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Hauptverfasser: Erickson, Shawn David, Baldwin, John J, Dolle, III, Roland Ellwood, Inglese, James, Ohlmeyer, Michael H. J, Ho, Koc-Kan, Bohnstedt, Adolph C, Kultgen, Steven G, Conti, Paolo Giovanni Martino, Leysen, Dirk, van der Louw, Jaap
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creator Erickson, Shawn David
Baldwin, John J
Dolle, III, Roland Ellwood
Inglese, James
Ohlmeyer, Michael H. J
Ho, Koc-Kan
Bohnstedt, Adolph C
Kultgen, Steven G
Conti, Paolo Giovanni Martino
Leysen, Dirk
van der Louw, Jaap
description Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, -O-alkyl or -S-alkyl. A representative example is:
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J ; Ho, Koc-Kan ; Bohnstedt, Adolph C ; Kultgen, Steven G ; Conti, Paolo Giovanni Martino ; Leysen, Dirk ; van der Louw, Jaap</creator><creatorcontrib>Erickson, Shawn David ; Baldwin, John J ; Dolle, III, Roland Ellwood ; Inglese, James ; Ohlmeyer, Michael H. J ; Ho, Koc-Kan ; Bohnstedt, Adolph C ; Kultgen, Steven G ; Conti, Paolo Giovanni Martino ; Leysen, Dirk ; van der Louw, Jaap ; Pharmacopeia Drug Discovery, Inc</creatorcontrib><description>Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, -O-alkyl or -S-alkyl. 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title Pyrimidine derivatives as IL-8 receptor antagonists
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