Pyrimidine derivatives as IL-8 receptor antagonists

Pyrimidine derivatives as IL-8 receptor antagonists

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen...

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Bibliographische Detailangaben
Hauptverfasser: Erickson, Shawn David, Baldwin, John J, Dolle, III, Roland Ellwood, Inglese, James, Ohlmeyer, Michael H. J, Ho, Koc-Kan, Bohnstedt, Adolph C, Kultgen, Steven G, Conti, Paolo Giovanni Martino, Leysen, Dirk, van der Louw, Jaap
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, -O-alkyl or -S-alkyl. A representative example is: