Process for producing polypeptide having disulfide bond

The invention relates to a DNA that enables co-expression of a protein disulfide isomerase and a polypeptide having disulfide bonds. The invention further relates to a process of producing polypeptides using the DNA and a process of enhancing the efficiency of formation of correct disulfide bond in...

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Bibliographische Detailangaben
Hauptverfasser: Udaka, Shigezo, Sato, Seiji, Kudo, Toshiyuki, Oka, Shusaku, Higashikuni, Naohiko, Kondo, Masaaki
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to a DNA that enables co-expression of a protein disulfide isomerase and a polypeptide having disulfide bonds. The invention further relates to a process of producing polypeptides using the DNA and a process of enhancing the efficiency of formation of correct disulfide bond in an expression system of a gene recombinant polypeptide having disulfide bonds.