Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast

Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast

A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4′,3′-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4) has been discovered. These intr...

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Hauptverfasser: Hunt, Jay D, Bazan, Haydee E, Marcheselli, Victor L, Gomez, Julio Alvarez Builla, Bazan, Nicholas G
Format: Patent
Sprache:eng
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Zusammenfassung:A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4′,3′-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4) has been discovered. These intracellular-binding platelet-activating factor antagonists were found to inhibit both in vivo and in vitro tumor growth and angiogenesis where the angiogenesis is stimulated by basic fibroblast growth factor.